摘要
近年来的研究证实,上皮-间质转化(epithelial-mesenchymal transition, EMT)对呼吸系统发育和疾病有重要作用。细胞间的连接缺失是EMT的关键环节。各类黏附分子的平衡表达对于维持上皮细胞正常结构和功能稳态有重要意义。本文综述了EMT在肺发育、肺损伤修复以及肺部慢性疾病中的研究进展,并结合EMT分子事件的详细过程,就细胞连接结构和细胞黏附分子对EMT的影响作一概述。
Epithelial-mesenchymal transition(EMT) plays an important role in the development and pathogenesis of respiratory system. Epithelial cells are characterized by well-developed, intercellular contacts, whereas EMT triggers the sequential destabilization of cell-cell adhesive junctions. The dynamic remodeling of the epithelial cell adhesion molecules is important for maintaining the integrity and normal function of epithelium. This paper reviews the research progress of EMT in lung development, lung injury repair and chronic lung diseases, and summarizes the effect of cell junctions and cell adhesion molecules on EMT molecular events.
作者
谭眉灵
龙春姣
蒋旺
王金美
皮姣
秦晓群
向阳
TAN Mei-Ling;LONG Chun-Jiao;JIANG Wang;WANG Jin-Mei;PI Jiao;QIN Xiao-Qun;XIANG Yang(Department of Physiology,School of Basic Medical Science,Central South University,Changsha 410078,China)
出处
《生理学报》
CAS
CSCD
北大核心
2020年第5期605-616,共12页
Acta Physiologica Sinica
基金
supported by grants from the National Natural Science Foundation of China (No. 81670002)
the Innovation Program for Graduate Students of Central South University
China (No. 1053320184091)
关键词
上皮-间质转化
肺
气道上皮细胞
细胞连接
黏附分子
epithelial-mesenchymal transition
lung
airway epithelium
cell junction
adhesion molecules
