长脉宽1064 nm Nd∶YAG与2940 nm Er∶YAG激光联合口内和皮肤治疗改善鼻唇沟皱纹的效果

Combined intraoral and cutaneous using of long pulsed 1064 nm and 2940 nm lasers in facial rejuvenation:a prospective study of two consecutive patients

目的探讨长脉宽1064 nm Nd∶YAG与2940 nm Er∶YAG激光口内与皮肤联合治疗鼻唇沟皱纹的有效性及安全性。方法2019年2月至2020年3月,上海时光整形外科医院皮肤科对21例(年龄30~50岁,平均38岁)不同程度鼻唇沟皱纹的女性美容就医者进行6次长脉宽1064 nm Nd∶YAG与2940 nm Er∶YAG激光治疗,联合口内黏膜与面部皮肤照射,间隔1个月。分别于治疗前、3次治疗(3个月)、6次治疗(6个月)用VISIA拍摄照片;由2位未参与治疗的皮肤科医师评估效果,用改良Fitzpatrick皱纹量表(MFWS)评估鼻唇沟严重程度。分析美容就医者的满意度自评,记录治疗的不良反应。结果激光治疗3个月观察到轻度和中度鼻唇沟皱纹明显改善,鼻唇沟MFWS评分由1.59降至0.90,重度鼻唇沟有淡化,但差异无统计学意义;6个月后,18例美容就医者鼻唇沟皱纹改善;7例轻度鼻唇沟均改善,10例中度鼻唇沟有9例改善,4例重度鼻唇沟2例改善,MFWS评分降至0.57(P<0.001);18例患者自评满意。2例患者在治疗时有可耐受的轻度烧灼痛,2例术后出现短暂的色素沉着,未见其它不良反应。结论长脉宽1064 nm Nd∶YAG与2940 nm Er∶YAG激光联合口内和皮肤治疗是一种安全有效的中面部紧致方法。

Objective To study the effectiveness and safety of combined intraoral and cutaneous using of long pulsed 1064 nm Nd∶YAG and 2940 nm Er∶YAG lasers in facial rejuvenation.Methods Twenty-one female patients with different grades of nasolabial fold were treated with 6 sessions of the combination lasers therapy once a month.Standardized photographs of VISIA were taken before and after treatment to record any changes of facial contour and nasolabial folds.The efficacy assessment was judged by two non-group experienced dermatologists using modified Fitzpatrick Wrinkle Scale(MFWS),based on the VISIA photos at base line,twelve-week and six-month after treatment.Self-scoring of 5-level satisfaction from patients was also collected and analyzed.Any side effects and complications were recorded.Results At 12 weeks,mild and moderate nasolabial folds were improved notably,the mean value of MFWS decreased from 1.59 to 0.90,whereas severe nasolabial folds had no remarkable improvement.Six-month after treatment,18 patients had notable improved,among them:five out of 7 mild cases,9 out of 10 moderate cases and 2 out of 4 severe cases,and the mean value of MFWS significantly decreased to 0.57(P<0.001).The general satisfactory rate of self-scoring was 86%.Two patients had tolerable light burning pain during treatment and two patients got temporary pigmentation that vanished in three months.There were no other adverse reactions and complications.Conclusion Combined intraoral and cutaneous using oflong pulse 1064 nm Nd∶YAG laser and 2940 nm Er∶YAG laser is a safe and effective therapy for facial rejuvenation.