水光注射联合保湿修复霜治疗玫瑰痤疮的疗效

Efficacy of water injection therapy combined with medical moisturizing repair cream on rosacea

目的探讨水光注射联合医用保湿修复霜治疗玫瑰痤疮的疗效和安全性。方法2018年1—12月,陆军军医大学第一附属医院皮肤科将100例玫瑰痤疮患者分为联合组、水光组、保湿组。联合组及水光组给予水光注射,每月1次,共治疗3个月;联合组及保湿组使用外用医用保湿修复霜每日早晚,各1次,共治疗3个月。治疗师根据皮损评分标准进行评估,对不良反应进行记录。结果治疗12周后,联合组、水光组、保湿组治疗前后积分差值分别为10.01±1.23、9.18±0.92、4.63±1.01,3个组患者治疗后红斑、丘疹脓疱、瘙痒等症状积分都有好转,联合组效果明显优于水光组(t=0.678,P<0.05)和保湿组(t=1.195,P<0.05),差异有统计学意义。3个组有效率分别为94.38%、89.91%、48.12%;均未见严重不良反应。结论水光注射联合医用保湿修复霜治疗玫瑰痤疮安全、有效。

Objective To evaluate the efficacy and safety of water injection therapy combined with medical moisturizing repair cream in the treatment of rosacea.Methods Total of 100 patients with types I and II rosacea in the Department of Dermatology,the First Affiliated Hospital of Army Medical University were randomly divided into three groups:comprehensive group(treatment group),hydrate group(control group 1)and moisturizing group(control group 2).Comprehensive group and water light group were given water injection therapy,once a month,a total of 3 times of treatment;in the comprehensive group and the moisturizing group,topical medical moisturizing repair cream was used once in the morning and in the evening,for a total of 12 weeks.After unified training,the therapists evaluated the skin lesions according to the scoring criteria and recorded the adverse reactions,for a total of 12 weeks.Results After 12 weeks of treatment,the integral difference values before and after treatment were 8.01±2.43,7.68±2.16 and 5.63±2.19 respectively in the comprehensive group,the water injection therapy group and the moisturizing group,with statistically significant differences(P<0.05).The effective rates of the three groups were 94.38%,89.91%and 48.12%.No serious adverse reactions were observed.Conclusions The water injection therapy combined with medical moisturizing and repairing cream is safe and effective in the treatment of rosacea;it is more effective than the moisturizing and repairing cream.The water injection therapy combined with medical moisturizing and repairing cream has advantages but is not obvious enough.