2型糖尿病合并高尿酸血症青年患者代谢相关因素分析

Metabolic correlation factors analysis on type 2 diabetes mellitus complicated with hyperuricemia for young people

目的 探讨2型糖尿病合并高尿酸血症青年患者的临床特征及相关因素。方法 回顾性分析2013年1月—2017年6月在南充市第二人民医院就诊的20~45岁2型糖尿病合并高尿酸血症青年患者319例。将患者按诊断高尿酸血症的标准分为高尿酸血症组(156例)和血尿酸正常组(163例);分析两组的一般情况和临床资料,Logistic多元逐步回归分析相关危险因素。结果 与血尿酸正常组比较,高尿酸血症组的体重指数(BMI)、甘油三酯(TG)、尿酸(UA)、收缩压、舒张压、脉压、空腹胰岛素水平(FINS)、胰岛素抵抗指数(HOMA-IR)、血肌酐(Scr)、糖化血红蛋白(GHb)、代谢性疾病(高血压、代谢综合征和超重或肥胖)发病率和睡眠质量差患者构成比均升高(P<0.05)。UA与TG、Scr呈正相关(rs=0.165和0.698,P<0.05)。Logistic多元逐步回归分析显示高血压[■=2.584(95% CI:1.233,5.414)]、代谢综合征[■=6.751(95% CI:3.514,12.968)]和睡眠质量差[■=2.229(95% CI:1.290,3.851)]为2型糖尿病并发高尿酸血症青年患者的危险因素。结论 2型糖尿病合并高尿酸血症青年患者可能与高血压、代谢综合征及睡眠质量差相关。

Objestive To explore the factors of type 2 diabetes mellitus complicated with hyperuricemia in young people to provide a reference for prophylaxis and treatment of the disease.Methods A total of 319 patients(aged 20 to 45 years) with type 2 diabetes mellitus complicated with hyperuricemia in this hospital from January2013 to June 2017 were retrospectively analyzed.The patients were divided into two groups:hyperuricemia (HUA)group (n=156) and non-hyperuricemia (NUA) group (n=163),according to the diagnostic criteria of hyperuricemia.The general condition and clinical data in two groups was analyzed.The Logistic regress analysis was performed to explore the risk factors.Results Compared with NUA group,BMI,TG,UA,systolic blood pressure,diastolic blood pressure,pulse pressure,FINS,HOMA-IR,Scr,GHb,the prevalence of metabolic diseases (hypertension,metabolic syndrome and overweight and/or obesity),and the composition ratio of patients with poor sleep quality were increased significantly in HUA group (P<0.05).The correlation coefficients of UA with TG and Scr were0.165 and 0.698 (P<0.05),suggesting positive relations.The logistic regression analysis showed that hypertension[■=2.584 (95%CI:1.233,5.414)],metabolic syndrome[■=6.751 (95%CI:3.514,12.968)]and poor sleep quality[■=2.229 (95%CI:1.290,3.851)]were identified as risk factors for type 2 diabetes mellitus complicated with hyperuricemia in young people.Conclusions Young type 2 diabetes mellitus patients with hyperuricemia may be closely related to metabolic diseases and poor sleep quality.