摘要
2019冠状病毒病(coronavirus disease 2019,COVID-19)已经成为人类社会迄今为止面临的最大挑战之一,具有传播广、重症及死亡率高的特点。现有研究发现COVID-19患者脑血管病发病率为0.5%,发病机制以栓塞和大动脉粥样硬化为主,大血管病变似乎在COVID-19相关卒中患者中更常见。病毒与血管紧张素转化酶2受体的相互作用、炎症反应和凝血紊乱等在COVID-19相关卒中发病中可能发挥作用。因此本文对COVI D-19患者的脑血管病流行病学、临床特点和发病机制进行归纳总结,以期更好地指导临床诊疗。
Coronavirus disease 2019(COVID-19)with a wide epidemic,high probability of deterioration and mortality,has become one of the biggest challenges for human society.It was reported that the prevalence of stroke in COVID-19 patients was 0.5%,with embolism and atherosclerosis as its main pathogenesis.There seemed to be more large-vessel stroke in COVID-19 patients.The interaction between the virus and ACE2 receptor,inflammation and coagulopathy played important roles in the pathogenesis of stroke in the COVID-19 patients.Therefore,this article aimed to summarize the relationship between severe acute respiratory syndrome coronavirus 2 and cerebrovascular diseases,to better guide the clinical diagnosis and treatment.
作者
顾聪
吴雪纯
曹勇军
刘春风
张霞
GU Cong;WU Xue-Chun;CAO Yong-Jun;LIU Chun-Feng;ZHANG Xia(Department of Neurology,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China)
出处
《中国卒中杂志》
2020年第11期1168-1174,共7页
Chinese Journal of Stroke
基金
苏州大学附属第二医院国家自然科学基金预研项目(SDFEYGJ1804)
2018年度苏州大学高校省级重点实验室开放课题(KJS1859)。
