黑逍遥散联合舒乐安定治疗女性围绝经期失眠的临床疗效及对神经内分泌系统的影响

Clinical value of Heixiaoyao Powder combined with Shule Anding in treating female perimenopausal insomnia and its effect on neuroendocrine system

目的观察黑逍遥散辅助舒乐安定治疗女性围绝经期失眠的临床疗效及对神经内分泌系统的影响。方法选取2016年9月—2019年10月收治的围绝经期失眠患者90例,按照随机数字表法分为观察组与对照组,每组45例。对照组单纯给予舒乐安定治疗,在此基础上观察组联合黑逍遥散治疗,两组均治疗4周。对比两组临床疗效,治疗前后神经内分泌系统指标[血清雌二醇(E2)、5-羟色胺(5-HT)、去甲肾上腺素(NE)]水平,睡眠质量[匹兹堡睡眠质量量表(PSQI)评分]改善情况及治疗安全性。结果观察组治疗总有效率为93.33%(42/45),高于对照组的77.78%(35/45),差异有统计学意义(P<0.05)。两组治疗后血清E2、5-HT、NE水平均较治疗前改善(P<0.05),且观察组血清E2、5-HT水平高于对照组,NE水平低于对照组,差异有统计学意义(P<0.05)。两组治疗后PSQI各维度评分及总分均较治疗前降低(P<0.05),且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗期间不良反应发生率15.56%(7/45)与对照组13.33%(6/45)比较,差异无统计学意义(P>0.05)。结论在舒乐安定基础上给予围绝经期失眠患者黑逍遥散治疗,疗效显著,可有效改善患者睡眠质量,可能与纠正神经内分泌系统紊乱有关,且该方案安全性具有保障。

Objective To analyze the clinical value of Heixiaoyao powder assisted Shule Ding on female perimenopausal insomnia and its influence on neuroendocrine system.Method From September 2016 to October 2019,90 patients with perimenopausal insomnia in our hospital were selected and divided into observation group and control group according to the random number table method,45 cases in each group.The control group was treated with pure sultalazolol,and the observation group was combined with Heixiaoyao powder.The two groups were treated for 4 weeks.The clinical effect,improvement of neuroendocrine system indexes(serum estradiol(E2),5-hydroxytryptamine(5-HT),noradrenaline(NE))and Pittsburgh Sleep Quality Scale(PSQI)score before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 93.33%(42/45)higher than that of the control group 77.78%(35/45)(P<0.05);After treatment,the levels of serum E2,5-HT and NE in the observation group were higher than those in the control group(P<0.05),and the levels of NE in the observation group were lower than those in the control group(P<0.05);After treatment,PSQI scores and total scores of the two groups were lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05);There was no significant difference in the incidence of adverse reactions between the observation group 15.56%(7/45)and the control group 13.33%(6/45),the difference was not statistically significant(P>0.05).Conclusion Heixiaoyao powder is given to perimenopausal insomnia patients on the basis of Shule Anding,it can effectively improve the sleep quality of the patients,which may be related to the correction of neuroendocrine system disorder,and the safety of the program is guaranteed.