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P16在宫颈癌及癌前病变脱落细胞中表达的临床意义研究 被引量:2

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摘要 目的:探究P16在宫颈癌及癌前病变脱落细胞中表达的临床意义。方法:收集2019年5—10月在我科行宫颈脱落细胞P16免疫细胞化学染色检查的108例患者的病理资料,以活检后组织学结果为金标准,分析P16免疫细胞化学染色在各级别宫颈病变中阳性分布情况,计算P16免疫细胞化学染色在宫颈癌及高级别鳞状上皮内瘤变(HSIL)中表达的灵敏度、特异度、阳性预测值及阴性预测值。结果:宫颈癌及HSIL组P16蛋白阳性率显著高于宫颈炎组、低级别鳞状上皮内瘤变(LSIL)组,差异有统计学意义(P<0.01);P16蛋白检测宫颈癌及HISL的灵敏度、特异度、阳性预测值和阴性预测值分别是95.24%、80.30%、75.47%、96.36%。结论:随着宫颈病变程度的加重,P16蛋白表达阳性率不断增加,P16蛋白检测在发现宫颈癌及HSIL的病变中具有较好的灵敏度、特异度、阳性预测值和阴性预测值。P16蛋白表达情况可较好的预测HISL及以上病变,对我国宫颈癌的筛查有较好的临床意义。
出处 《医学理论与实践》 2020年第22期3821-3823,共3页 The Journal of Medical Theory and Practice
基金 惠州市科技计划项目(2019Y283)。
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