非酒精性脂肪性肝炎相关肝细胞癌特征及诊治进展

Characteristics and diagnosis and treatment progress of nonalcoholic steatohepatitis-related hepatocellular carcinoma

随着非酒精性脂肪性肝病(NAFLD)成为全球第一大慢性肝病后,非酒精性脂肪性肝炎相关肝癌(NASH-HCC)患者逐年增加,并渐成为肝癌最普遍病因。与其他病因肝癌明显不同,NASH-HCC与遗传因素、代谢综合征、肠道菌群改变和持续炎症等危险因素有关,临床上NASH-HCC多发生于年龄较大、男性、肥胖患者,并可由无肝硬化的NAFLD发展而来,在超声、CT及MRI检查中各有其相对特征性的表现。本文就NASH-HCC特征及诊治进展进行综述。

Considering that nonalcoholic fatty liver disease(NAFLD)has become the world′s first chronic liver disease,patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma(NASH-HCC)have increased dramatically,and it has leapt to the most common cause of liver cancer.Unlike other causes of liver cancer,NASH-HCC is strongly associated with the cluster of risk factors including genetic factors,metabolic syndrome,gut microbiota and chronic persistent inflammation.Clinically,NASH-HCC mostly occurs in aging,male,obese patients,and can evolve from NAFLD without cirrhosis.The relatively characteristic manifestations of NASH-HCC in ultrasound,CT and MRI examinations are significantly different from other causes of liver cancer.This article reviews the characteristics and the progress of NASH-HCC in diagnosis and treatment.