根除幽门螺杆菌与胃食管反流病疗效间的关系研究

Correlation Study of Helicobacter Pylori Resection With Treatment Efficacy in Gastroesophageal Reflux Disease Children

目的分析根除幽门螺杆菌(Hp)和胃食管反流病(gastroesophageal refiux disease,GERD)疗效的关系。方法将2017年3月—2019年12月本院收治Hp阳性的GERD患儿共102例为研究对象,随机将所有患儿分成根除Hp治疗组和未根除Hp治疗组两组,其中根除Hp组予以奥美拉唑为主根除Hp三联疗法,治疗时间为14 d,未根除Hp组只应用奥美拉唑口服14 d,14 d后所有患儿只应用奥美拉唑至总疗程2个月。结束治疗后均开展胃镜检查、24小时食管pH值监测检查、13碳尿素呼气试验与快速尿激酶检验。结果102例患儿中共90例完成研究,包含根除Hp治疗组46例和未根除Hp治疗组44例,同时根除Hp治疗组中所有患儿治疗后13碳尿素呼气试验与快速尿激酶检验结果均为阴性,均成功根除Hp。根除Hp治疗组和未根除Hp治疗组在治疗后酸反流及食管黏膜病变积分方面差异无统计学意义(P>0.05)。结论Hp根除治疗和GERD疗效之间无显著的相关性。

Objective To analyze the correlation of helicobacter pylori(Hp)resection with treatment efficacy in gastroesophageal reflux disease(GERD)children.Methods 102 GERD children from March 2017 to December 2019 were chosen and randomly divided into Hp resection group and Hp non-treatment group.Hp resection group was taken Hp triple therapy with omeprazole for 14d,Hp non-treatment group was just taken omeprazole for 14 d.Then both of groups were taken omeprazole from day 14 to 2 m later.After completion,gastroscopic examination,esophageal pH(pondus hydrogenii)monitoring for 24 hours,13C-Urea Breath Test and rapid urease test were performed.Results 90 of them were completed the test,including 46 cases in Hp resection group and 44 cases in Hp non-treatment group.13C-Urea Breath Test and rapid urease test showed negative results in Hp resection group.There were no significant differences on the acid reflux and esophageal mucosal lesion symptom scores between Hp resection group and Hp non-treatment group(P>0.05).Conclusion Hp resection has no obvious correlation with treatment efficacy in GERD children.