二硫代氨基甲酸酯及其衍生物在药物化学中的应用

Application of dithiocarbamates and their derivatives in medicinal chemistry

二硫代氨基甲酸酯及其衍生物具有独特的分子结构,这使其具有广泛的生物活性,已经成为近年来化工和药学领域研究的重点。本文综述了二硫代氨基甲酸酯及其衍生物的结构、合成和其在抗氧化、抗病毒、抗菌、抗肿瘤和抗阿尔茨海默病方面的生物活性,并对其今后的发展做出了展望。

Dithiocarbamates and their derivatives with unique molecular structures possess diverse biological activities,which have become the research focus in the chemical and pharmaceutical fields in recent years.Here,we will review the structures,synthesis as well as biological activities of dithiocarbamates and their derivatives in anti-oxidation,anti-virus,anti-bacterial,anti-tumor and anti-Alzheimer’s disease,and make a prospect for their development in the future.