泮托拉唑治疗上消化道溃疡出血患者的疗效及其对住院时间的影响

Effect of Pantoprazole on the treatment of patients with Upper Gastrointestinal Ulcer Bleeding and its Influence on the Hospitalization Time

目的探讨泮托拉唑治疗上消化道溃疡出血患者的疗效及其对住院时间的影响。方法选取我院2017年4月至2019年4月收治的上消化道溃疡出血患者78例,按随机法分为两组,均给予常规基础治疗,配合使用泮托拉唑治疗的39例患者为研究组,配合使用奥美拉唑治疗的39例患者为对照组。分析比较两组患者的治疗效果、治疗前后血常规指标水平、不良反应发生情况、住院时间、出血量、止血时间、总治疗费用。结果研究组患者治疗总有效率89.74%高于对照组(61.54%);研究组治疗后白细胞计数(WBC)、红细胞计数(RBC)、红细胞比容(Hct)、血红蛋白及血小板计数(Plt)水平均优于对照组,住院时间和止血时间短于对照组,不良反应发生率低于对照组,出血量以及总治疗费用均少于对照组(P<0.05)。结论在治疗上消化道溃疡出血患者时使用泮托拉唑,可以降低炎症程度,缩短止血时间,减少出血量,改善患者的临床指标及血常规指标,促进患者康复,缩短住院时间,减少不良反应的发生,安全可靠,治疗费用降低,有助于提升患者的接受度。

Objective To investigate the effect of pantoprazole on the treatment of patients with upper gastrointestinal ulcer bleeding and its influence on the hospitalization time.Methods Seventy-eight patients with upper gastrointestinal ulcer bleeding admitted to our hospital from April 2017 to April 2019 were randomly divided into two groups.Both groups were given conventional basic treatment,the study group was treated with pantoprazole,and the control group was treated with omeprazole.The treatment effect,level of blood routine index,the occurrence of adverse reactions,hospitalization time,bleeding volume,hemostasis time and total treatment cost of the two groups were analyzed and compared.Results The total effective rate of treatment in the study group was 89.74%,which was higher than the control group(61.54%);the levels of white blood cell count(WBC),red blood cell count(RBC),hematocrit(Hct),hemoglobin and platelet count(Plt)of the study group after treatment were better than those of the control group,hospitalization time and hemostasis time were shorter than control group,the incidence of adverse reactions is lower than that of the control group,and the bleeding volume and total treatment costs are less than those of the control group(P<0.05).Conclusion The use of pantoprazole in the treatment of patients with upper gastrointestinal ulcer bleeding can reduce degree of inflammation,shorten hemostasis time,reduce bleeding volume,improve clinical indicators and blood routine indicators of patients,promote recovery of patients,shorten hospitalization time,and reduce adverse reactions.It is safe and reliable,and treatment costs are reduced,which helps to improve patient acceptance.