氧化石墨烯在钛植入物表面改性应用中的研究进展

Application of Graphene Oxide in Surface Modification of Titanium Implants

金属钛以其优良的理化性质和良好的生物相容性被广泛应用于牙科种植和骨科植入领域,但钛植入材料仍可能发生移植整合失败或者发生以植入物为中心的感染。为了优化种植体性能,对钛表面进行物理、化学、生物改性已经成为研究热点。氧化石墨烯因具有良好的机械性能、骨传导性、骨诱导性、生物相容性、抗菌性、易功能化等特点,目前越来越多地被应用于复合生物材料的研发。本文将近年来氧化石墨烯在金属钛表面改性研究中的应用情况进行综述。

Titanium is widely used as dental implant and orthopedic implant due to its excellent physical and chemical properties and good biocompatibility.However,graft integration failure or implant centered infection may occur with titanium implants.In recent years,physical,chemical,and biological modifications of titanium surface for optimizing implant properties have become a research focus.Graphene oxide has good mechanical properties,bone conductivity,bone inductivity,biocompatibility,antibacterial property,and easy functionalization.At present,graphene oxide is increasingly applied in the research and development of composite biological materials.In this paper,the application of graphene oxide to surface modification of titanium is reviewed.