肺部多发结节的诊断、分期和治疗现状

Clinical diagnostic criteria,stage classification,and treatment strategy for multiple primary lung cancer

多原发肺癌(multiple primary lung cancer,MPLC)是指同一个体肺内存在两个或两个以上肺癌病灶,其诊断难点在于与肺癌肺内转移(metastatic nodules)相鉴别。传统MPLC诊断主要基于组织病理学,如今分子生物学检测方法也相继应用于MPLC辅助诊断。关于MPLC治疗的手术方式目前尚无定论,受肿瘤个数、位置以及患者心肺储备功能等多方面因素的影响。本文就现今MPLC的诊断、分期和治疗策略进行系统综述。

Multiple primary lung cancer(MPLC)is defined as the simultaneous or successive occurrence of two or more primary lung cancers in the same individual,and distinguishing MPLC from intrapulmonary metastasis can be challenging.There is ambiguity in the treatment of such tumors,which can be influenced by the number,distribution of MPLC as well as patient cardiopulmonary function.This review will summarize current understanding of diagnostic criteria,stage classification,and treatment strategy for multiple primary lung cancer.