复方马齿苋颗粒对2型糖尿病患者血糖和炎性因子水平的影响

The effect of compound purslane granules on blood glucose and inflammatory factors in patients with type 2 diabetes

目的探讨复方马齿苋颗粒对2型糖尿病(T2DM)患者血糖及炎性因子水平的影响。方法将2019年1-9月垫江县中医院收治的T2DM患者随机分为对照组和观察组,各35例。对照组给予常规基础治疗,观察组在对照组治疗方案的基础上经中医辨证后加用复方马齿苋颗粒,连续治疗8周。观察两组患者治疗前后空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平,并比较疗效。结果治疗后,观察组的总有效率高于对照组(88.57%vs.65.71%,P<0.05);两组FBG、2 h PBG、HbA1c和炎性指标TNF-α、IL-6、CRP水平较治疗前下降,差异均有统计学意义(P<0.05);治疗后,观察组HbA1c水平低于对照组(P<0.05)。结论复方马齿苋颗粒对T2DM病患者控制血糖和降低炎性因子水平有较好效果,值得临床推广。

Objective To study the effect of blood glucose and inflammatory factors of compound purslane granules in the treatment of patients with type 2 diabetes(T2DM).Methods The patients with T2DM treated in Dianjiang TCM Hospital from January to September 2019 were randomly divided into observation group and control group,35 cases in each.The control group was given routine treatment,in addition to the routine treatment,the observation group was given compound purslane granules.Eight weeks after treatment,the clinical effect,blood glucose,glycosylated hemoglobin(HbA1c),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),reactive protein(CRP)were observed.Results After the treatment,the clinical total effective rate of the treatment group was higher than that of the control group(88.57%vs.65.71%,P<0.05);the FBG,2 h PBG,TNF-α,IL-6 and CRP concentrations after the treatment were lower than those before the treatment(P<0.05);after the treatment,and the HbA1c concentration in observation group was lower than that in control group(P<0.05).Conclusion Compound purslane granules is obviously effective in the treatment of T2DM,and can significantly reduce the concentration of blood glucose and inflammatory factors,which deserves to be promoted in clinical application.