抗原85复合物的致病机制及其在结核病疫苗研制中的应用进展

Pathogenic mechanism of Ag85 complex and its application progress in the development of tuberculosis vaccine

结核分枝杆菌(MTB)的传播亟需开发有效的疫苗来控制。目前已鉴定出多种MTB免疫原性分子,其中,抗原85(Ag85)复合物(Ag85A、Ag85B和Ag85C)是重要的毒力因子,介导MTB的黏附和侵袭及其细胞壁的合成。Ag85抗原已被用作多种新型疫苗的构建中,如重组减毒疫苗、蛋白佐剂疫苗和病毒载体疫苗。作者综述了Ag85复合物的致病机制及其在结核病疫苗研制中的应用进展,探讨了Ag85复合物作为抗原在不同类型疫苗研制中的作用。

Effective vaccines are urgently needed to control the transmission of Mycobacterium tuberculosis(MTB).A variety of MTB immunogenic molecules have been identified by now.And of them,the antigen 85(Ag85)complex(Ag85A,Ag85B and Ag85C)is an important virulence factor,it could mediate the adhesion and invasion of MTB and the synthesis of the cell wall.Ag85 complex has been used in the construction of many new vaccines,such as recombinant attenuated vaccines,protein adjuvant vaccines and virus vector vaccines.In this paper,pathogenic mechanism of Ag85 complex and its application progress in the development of tuberculosis vaccine are reviewed,and the effects of Ag85 complex as antigens in developing different types of tuberculosis vaccines are also investigated.