抗苗勒管激素与女性生殖结局关系的研究进展

Research progress of anti-Müllerian hormone in female reproductive outcomes

抗苗勒管激素(AMH)是一种二聚体糖蛋白,是转化生长因子-β(TGF-β)家族的一员。作为一种生物标志物,AMH被首次应用于卵巢储备的定量评估距今已有17年,AMH的应用范围已逐渐扩大。AMH在卵巢内调控卵泡发育,在性腺外也发挥重要的神经内分泌作用。AMH与流产、活产、早产、妊娠期高血压疾病等生殖结局存在一定的相关性。现综述AMH与女性生殖结局关系的最新研究进展,以期为妇产科临床工作开展提供参考依据。

Anti-Müllerian hormone(AMH)is a dimeric glycoprotein and a member of the transforming growth factor-beta(TGF-β)family.It has been more than 17 years since the measurement of serum AMH as a biomarker first allowed the quantitative assessment of ovarian reserve.Meanwhile,the implication of AMH has been expanding.AMH regulates follicular development in the ovary and also plays an important neuroendocrine role outside the gonads.There are certain associations between AMH and reproductive outcomes such as miscarriage,live birth,preterm birth and hypertensive disorders in pregnancy.This article reviews the latest research progress of AMH in association with reproductive outcomes,with a view to provide a reference for the clinical work of obstetrics and gynecology.