高频重复经颅磁刺激对躯体化障碍的治疗效果

Therapeutic effect of high frequency repetitive transcranial magnetic stimulation on somatization disorders

目的观察高频重复经颅磁刺激(10 Hz,rTMS)对躯体化障碍患者的治疗效果。方法74例躯体化障碍患者随机分为研究组(rTMS)38例和对照组(舍曲林)36例,治疗8周。研究组给予10 Hz rTMS治疗,对照组给予抗抑郁剂舍曲林。两组患者在基线时和治疗后每隔2周各测评汉密尔顿抑郁量表24项(HAMD-24)及不良反应量表(TESS)。以HAMD减分率评价疗效、TESS评价不良反应。结果治疗8周后,两组HAMD-24评分和疗效比较,差异无统计学意义(P>0.05);在各时期不良反应量表评定中,研究组均低于对照组,差异有统计学意义(P<0.05)。结论高频重复经颅磁刺激和舍曲林治疗躯体化障碍的疗效相当,前者的不良反应较少。

Objective To observe the therapeutic effect of high frequency repetitive transcranial magnetic stimulation(10 Hz,rTMS)on the patients with somatization disorders.Methods A total of 74 patients with somatization disorders were randomly divided into study group(rTMS)in 38 cases and control group(sertraline)in 36 cases,treated for 8 weeks.The study group was given 10 Hz rTMS for treatment.The control group was given the antidepressant sertraline for treatment.The hamilton depression scale 24(HAMD-24)and the adverse reaction scale(TESS)were evaluated at baseline and every 2 weeks after treatment in both groups.Efficacy was evaluated by HAMD reduction rate,and adverse reactions were evaluated by TESS.Results After 8 weeks of treatment,there was no statistically significant difference in the HAMD-24 score and efficacy between the two groups(P>0.05).In the evaluation of adverse reaction scales in each period,the study group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion High-frequency repetitive transcranial magnetic stimulation and sertraline are effective in the treatment of somatization disorders,and the former has fewer adverse reactions.