秋水仙碱致尿失禁

Urinary incontinence due to colchicine

1例55岁男性肝复杂泡型包虫病患者有痛风病史4年余,入院等待远程会诊结果和准备接受择期右半肝切除术时,出现双足肿胀、皮温高等症状。实验室检查示尿酸530μmol/L,风湿因子阴性,考虑痛风急性发作。给予秋水仙碱0.5 mg口服、3次/d。首次服药后约10 h,患者出现尿失禁。考虑尿失禁可能与秋水仙碱有关,立即停用该药。停药24 h后尿失禁症状消失。患者自行再次服用秋水仙碱后尿失禁症状复现,再次停用该药后未再出现尿失禁。

A 55-year-old male patient with hepatic complex alveolar echinococcosis,who had a history of gout for more than 4 years,developed swelling and high skin temperature of feet when he waited for the result of remote consultation and prepared for optional right hemihepatectomy in the hospital.Laboratory tests showed that uric acid was 530μmol/L and rheumatic factor was negative.Acute gout attack was considered.He was treated with oral colchicine 0.5 mg thrice daily.About 10 hours after the first administration,the patient developed urinary incontinence.According to the consultation results,it was considered that the urinary incontinence might be related to colchicine.Colchicine was stopped immediately.The symptoms of urinary incontinence disappeared 24 hours after drug withdrawal.The symptoms of urinary incontinence recurred after the patient took the drug again by himself.Urinary incontinence did not recur after the colchicine withdrawal again.