多维元素片(29)致甲状腺功能异常

Thyroid dysfunction induced by vitamins with minerals tablets(29)

1例29岁女性患者因准备怀孕服用多维元素片(29)(每片含碘150μg)近1年。孕前检查发现甲状腺功能异常,游离甲状腺素(FT4)23.2 pmol/L,游离三碘甲状腺原氨酸(FT3)5.56 pmol/L,促甲状腺激素(TSH)0.10 mU/L。遵医嘱立即停用多维元素片(29)。停用该药5 d后复查甲状腺功能仍异常,FT421.2 pmol/L,FT35.39 pmol/L,TSH 0.08 mU/L,促甲状腺素受体抗体<0.3 U/L;停药59 d后复查,甲状腺功能恢复正常,FT416.35 pmol/L,FT34.97 pmol/L,TSH 2.36 mU/L,考虑患者的甲状腺功能异常为多维元素片(29)所致。

A 29-year-old female patient took vitamins with minerals tablets(29)(each tablet contains 150μg of iodine)for nearly one year because she was preparing for pregnancy.Abnormal thyroid function was found in pre-pregnancy examination.Her free thyroxine(FT4)was 23.2 pmol/L,free triiodothyronine(FT3)was 5.56 pmol/L,and thyroid stimulating hormone(TSH)was 0.10 mU/L.According to the doctor′s advice,she stopped taking vitamins with minerals tablets(29)immediately.Five days after discontinuation of the drug,her FT4 was 21.2 pmol/L,FT3 was 5.39 pmol/L,TSH was 0.08 mU/L,and thyrotropin receptor antibody was<0.3 U/L.The results of re-examination on day 59 after drug withdrawal showed FT416.35 pmol/L,FT34.97 pmol/L,and TSH 2.36 mU/L.It was considered that the patient′s thyroid dysfunction was caused by vitamins with minerals tablets(29).