摘要
One key aspect of human aging is the dysregulation of theimmune system.As we age,our body's defense systemweakens,leading to declined responses to infection by newpathogens and a decreased ability to become immunized(Goronzy and Weyand,2013;Goronzy and Weyand,2017).As a result,elderly people are more susceptible to theseasonal flu caused by the constantly mutating influenzaviruses.Another manifestation of immune system aging islow grade chronic inflammation,which is linked to manyage-related diseases(Glass et al.,2010;Ferrucci andFabbri,2018).Recent comprehensive characterization ofcellular and molecular changes caused by aging in mam-mals further revealed the importance of immune systemaging,as the up-regulation of genes involved in the inflam-matory/immune response turned out to be a highly con-served signature across species and across different organsand tissues(Frenk and Houseley,2018;Ma et al.,2020;Schaum et al.,2020;Tabula Muris,2020).In addition,senolytic drugs targeting senescent cells which is a sourceof chronic inflammation showed great promise in retardinglpreventing many age-related pathologies(Kirkland andTchkonia,2020).
