血清β-(1,3)-D-葡聚糖在新生儿侵袭性真菌感染诊断中的临床意义

The clinical significance of serum β-(1,3)-D-glucan in the diagnosis of invasive fungal infection in neonates

目的研究血清β-(1,3)-D-葡聚糖在新生儿侵袭性真菌感染中的表达水平,探讨其对该病诊断的应用价值。方法选取2019年1月到2020年6月期间本院新生儿科诊治的100例侵袭性真菌感染患儿,纳入研究组;选取同期接受常规体检的100例健康新生儿,纳入对照组;对两组患儿进行血清β-(1,3)-D-葡聚糖检测,并行统计学分析。结果研究组的血清β-(1,3)-D-葡聚糖检测水平高于对照组(P<0.05);血清β-(1,3)-D-葡聚糖诊断新生儿侵袭性真菌感染的敏感度、特异度、阳性预测值、阴性预测值分别为78.00%、63.00%、67.83%、74.12%。结论血清β-(1,3)-D-葡聚糖在新生儿侵袭性真菌感染中呈高表达水平,可为临床诊断提供重要的参考依据,值得推行。

Objective To investigate the expression level of serum β-(1,3)-D-glucan in invasive fungal infection of neonates and its diagnostic value.Methods A total of 100 neonates with invasive fungal infection treated in department of neonatology of our hospital from January 2019 to June 2020 were selected as study group,100 healthy neonates who received conventional check-up as control group.Serum β-(1,3)-D-glucan was detected and was statistically analyzed.Results The level of serum β-(1,3)-D-glucan in the study group was higher than that in the control group(P<0.05).The sensitivity,specificity,positive predictive value,and negative predictive value of serum β-(1,3)-D-glucan in the diagnosis of invasive fungal infection in neonates were 78.00%,63.00%,67.83%,and 74.12%,respectively.Conclusion The high expression of serum β-(1,3)-D-glucan in neonatal invasive fungal infection can provide an important reference for clinical diagnosis,which is worthy of promotion.