镁在偏头痛发病机制及治疗中的研究进展

Research Progress of Magnesium in Pathogenesis and Treatment of Migraine

镁是细胞内第二丰富的阳离子,在许多生命活动中发挥重要作用。缺镁可诱发皮层扩布性抑制(cerebral spreading depression,CSD),促进血小板聚集,影响5-羟色胺(5-hydroxytryptamine,5-HT)受体功能及多种神经递质的合成和释放。偏头痛是一种高度流行和致残的神经系统疾病,发病机制复杂多样,尚不明确。近年来镁在偏头痛中的作用逐渐受到重视,有研究表明口服或静脉补充镁可治疗并预防偏头痛发作。现就镁在偏头痛发病机制及治疗中的作用进行综述,旨在为临床治疗偏头痛提供更多理论依据。

Magnesium is the second most abundant cation in cells and plays an important role in many life activities.Magnesium deficiency can induce cerebral spreading depression(CSD),promote platelet aggregation,affect the function of 5-HT receptor and the synthesis and release of a variety of neurotransmitters.Migraine is a highly prevalent and disabling neurological disease with a complex and diverse pathogenesis that remains unclear.In recent years,the role of magnesium in migraine has received increasing attention.Some studies have shown that oral or intravenous magnesium supplementation can treat and prevent migraine attacks.This paper reviews the role of magnesium in the pathogenesis and treatment of migraine in order to provide more theoretical basis for clinical treatment of migraine.