氨溴特罗联合复方异丙托溴铵辅助治疗小儿肺炎的临床效果

Clinical effect of ambroxol combined with compound ipratropium bromide in adjuvant treatment of pneumonia in children

目的观察氨溴特罗联合复方异丙托溴铵辅助治疗小儿肺炎的临床效果。方法选取2018年2月-2019年4月广州市花都区第二人民医院儿科收治的支气管肺炎患儿150例,采用随机数字表法分为治疗组和对照组各75例。对照组采取常规治疗,治疗组在对照组的基础上给予氨溴特罗联合复方异丙托溴铵治疗。比较2组患儿的临床疗效、症状体征改善时间及不良反应。结果治疗组总有效率为93. 3%,明显高于对照组的73. 3%(χ2=10. 800,P=0. 001)。治疗组患儿咳嗽、湿啰音、哮鸣音改善时间均明显短于对照组(P <0. 01)。治疗组患儿不良反应总发生率为2. 7%,低于对照组的12. 0%(χ2=4. 807,P=0. 028)。结论氨溴特罗联合复方异丙托溴铵辅助治疗小儿肺炎效果较好,可有效改善患儿的症状体征,具有广泛应用价值。

Objective To observe the clinical effect of ambroxol combined with compound ipratropium bromide in adjuvant treatment of pneumonia in children. Methods 150 children with bronchial pneumonia admitted to the Department of Pediatrics of the Second People’s Hospital of Huadu,Guangzhou from February 2018 to April 2019 were selected,and they were divided into treatment group and control group by random number table,75 cases in each group. The control group received conventional treatment,and the treatment group was treated with ambroxol combined with compound ipratropium bromide on the basis of the control group. The clinical efficacy,improvement time of symptoms and signs and adverse reactions of the two groups were compared. Results The total effective rate of the treatment group( 93. 3%) was significantly higher than that of the control group( 73. 3%)( χ2= 10. 800,P = 0. 001). The improvement time of cough,crackles and wheeze in the treatment group were significantly shorter than those in the control group( P < 0. 01). The total incidence of adverse reactions in the treatment group( 2. 7%) was lower than that in the control group( 12. 0%)( χ2= 4. 807,P = 0. 028). Conclusion Ambroxol combined with compound ipratropium bromide is effective in adjuvant treatment of pneumonia in children,it can effectively improve the symptoms and signs of children,and it has a wide range of application value.