妊娠期糖尿病患者分娩前糖化白蛋白水平与子代出生体重的相关性

Association of offspring birth weight with pre-delivery serum glycated albumin level in patients with gestational diabetes mellitus

目的探讨妊娠期糖尿病(GDM)患者分娩前的糖化白蛋白(GA)水平与子代出生体重之间的相关性。方法本文为回顾性研究。选取2014年1月到2017年12月在我院建档并且足月分娩的GDM患者。收集一般资料、孕前体质指数(BMI)、分娩前BMI、孕期体重增幅、分娩前1周GA、分娩时孕周、新生儿出生体重等临床数据。采用Pearson相关分析,探讨影响新生儿出生体重的因素。采用二元logistic回归模型,分析GA分级变量与新生儿超重(出生体重≥3.5 kg)风险的关系。结果共有108例GDM患者入选本研究。新生儿出生体重与孕前BMI、分娩前BMI、孕期体重增幅及分娩前GA水平呈正相关(r=0.251~0.561,均P<0.05)。与分娩前GA<11%组相比,分娩前GA为13%~15%和≥15%两组中新生儿超重风险显著增高,OR(95%CI)分别为6.786(1.642~28.041)和12.667(2.002~80.142)。结论足月分娩的GDM患者分娩前GA水平更高与新生儿超重风险增高相关。

Objective To explore the association between pre-delivery serum glycated albumin(GA)level and offspring birth weight in patients with gestational diabetes mellitus(GDM).Methods This is a retrospective study.GDM patients who had regular antenatal examinations and full-term delivery at our hospital from January 2014 to December 2017 were included in this study.Clinical data,including general information,pre-pregnancy body mass index(BMI),pre-delivery BMI,weight gain during pregnancy,GA level at one week before delivery,gestational age at parturition and neonate birth weight were collected.Pearson correlation analysis was used to analyze the correlation factors of neonate birth weight.The association of risk for neonate overweight(defined as birth weight≥3.5 kg)with GA grading variables was analyzed using binary logistic regression.Results A total of 108 GDM patents were enrolled in this study.The birth weight of offspring was positively associated with pre-pregnancy BMI,pre-delivery BMI,weight gain during pregnancy and pre-delivery GA level(r=0.251 to 0.561,all P<0.05).The relative risk of neonate overweight in the two groups of GDM patients with pre-delivery GA levels of 13%-15%and≥15%was higher than in those with the GA level of<11%.The OR(95%CI)was 6.786(1.642-28.041)and 12.667(2.002-80.142),respectively.Conclusion Among GDM patients with full-term birth,an increased risk of neonate overweight was associated with higher pre-delivery GA level.