淋巴瘤治疗后继发急性白血病研究进展

Research progress of secondary acute leukemia after treatment of lymphoma

淋巴瘤是起源于淋巴结和淋巴组织的免疫系统恶性肿瘤,按组织病理学改变,可分为霍奇金淋巴瘤(Hodgkin lymphoma,HL)和非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)。治疗相关性白血病(therapy-related leukemia,TRL),也被称为继发性白血病,是指原患肿瘤或非肿瘤性疾病者接受化疗和(或)放疗后若干年而发生的急性白血病。近年来,医疗水平的不断提高使得淋巴瘤的预后得到了很大的改善。

Therapy-related leukemia,also known as secondary leukemia,refers to acute leukemia that occurs several years after chemotherapy and/or radiotherapy in patients with a primary tumor or non-tumor disease.This article reviews the risk factors,pathogenesis,prognosis and treatment progress of secondary acute leukemia after lymphoma treatment.