中晚期原发性肝癌TACE介入微创治疗的疗效和对肝功能的影响

Observation on the Efficacy of TACE Interventional Minimally Invasive Therapy for Advanced Primary Hepatocellular Carcinoma and its Effect on Liver Function

目的探讨中晚期原发性肝癌经肝动脉化疗栓塞(TACE)术介入微创治疗的疗效和对肝功能的影响。方法选取100例中晚期原发性肝癌患者为研究对象,抽取时间为2017年6月—2018年12月期间,采用随机数字表法将患者平均分为两组,其中50例采用肝动脉灌注(TAI)介入治疗的患者纳入对照组,另外50例采用TACE介入微创治疗的患者纳入观察组,对比两组患者的治疗效果、肝功能情况及不良情况发生率。结果经比较,观察组94.0%的治疗有效率较对照组80.0%的治疗有效率明显提升,差异有统计学意义(P<0.05);治疗前,两组患者ALT、AST及总胆红素水平无明显区别,差异无统计学意义(P>0.05);治疗后,两组均有所下降,且观察组下降幅度较对照组明显更大,差异有统计学意义(P<0.05);观察组发热2例、腹痛1例及恶心呕吐1例,不良反应发生率8.00%,对照组发热4例、腹痛3例及恶心呕吐5例,不良反应发生率24.00%,组间对比,差异有统计学意义(P<0.05)。结论针对中晚期原发性肝癌患者,采用TACE介入微创治疗效果显著,患者的肝功能情况得以明显改善,且不良反应少,极具临床推广价值。

Objective To investigate the effect of TACE interventional minimally invasive treatment on liver function in patients with advanced primary liver cancer.Methods 100 patients with advanced primary liver cancer were selected from June,2017 to December,2018.The patients were divided into two groups on average by using random number table method.Among them,50 patients with TAI intervention were included in the control group,and 50 patients with TACE intervention and minimally invasive treatment were included in the observation group.The treatment effect,liver function and adverse conditions of the two groups were compared.Results After comparison,94.0%of the effective rate in the observation group was significantly higher than80.0%in the control group(P<0.05).Before treatment,there was no significant difference in ALT,AST and total bilirubin levels between the two groups(P>0.05).After treatment,there was decrease in the two groups,and the decrease in the observation group was significantly greater than that in the control group(P<0.05).There was 2 cases of fever,1 case of abdominal pain and1 case of nausea and vomiting in the observation group.The incidence of adverse reactions was 8.00%.In the control group,there were 4 cases of fever,3 cases of abdominal pain and 5 cases of nausea and vomiting.The incidence of adverse reactions was24.00%.There was significant difference between the two groups(P<0.05).Conclusion For patients with advanced primary liver cancer,TACE interventional minimally invasive treatment is effective.The liver function of patients can be significantly improved,and the adverse reactions are less,which has great clinical value.