沙丁胺醇雾化吸入联合阿奇霉素对支气管哮喘患儿临床症状改善及气道重塑的影响

Effect of Salbutamol Combined with Azithromycin on the Improvement of Clinical Symptoms and Airway Remodeling in Children with Asthma

目的探讨沙丁胺醇雾化吸入联合阿奇霉素对支气管哮喘患儿临床症状改善及气道重塑的影响。方法选取2016年10月—2019年10月江苏大学附属医院收治的支气管哮喘患儿46例,采用单盲法进行分组,分为观察组(23例)和对照组(23例)。对照组给予沙丁胺醇雾化吸入治疗,观察组联合阿奇霉素治疗。治疗后,比较两组临床症状改善情况和气道重塑指标。结果观察组咳嗽缓解时间(3.29±0.83)d、气促缓解时间(3.02±0.54)d、哮鸣音消失时间(4.71±1.01)d短于对照组[(6.10±0.91)d、(5.93±0.61)d、(8.89±1.26)d],差异有统计学意义(P<0.05);治疗后,观察组血清中透明质酸(HA)[(8.29±1.02)ng/mL]、人层粘连蛋白(LN)[(32.73±3.14)ng/mL]、Ⅲ型前胶原(PCⅢ)[(22.57±3.21)pg/mL]水平低于对照组[(11.24±1.62)ng/mL、(48.95±4.62)ng/mL、(35.68±4.57)pg/mL],差异有统计学意义(P<0.05)。结论沙丁胺醇雾化吸入联合阿奇霉素治疗支气管哮喘患儿效果显著,可有效改善临床症状,预防气道重塑,值得临床推广。

Objective To investigate the effect of salbutamol atomization combined with azithromycin on the improvement of clinical symptoms and airway remodeling in children with asthma.Methods 46 children with asthma admitted to the hospital from October,2016 to October,2019 were divided into observation group(23 cases)and control group(23 cases)by single blind method.The control group received salbutamol atomization inhalation treatment,and based on this,the observation group received azithromycin treatment.After treatment,the improvement of clinical symptoms and airway remodeling indexes were compared between the two groups.Results The cough relief time(3.29±0.83)d,shortness of breath relief time(3.02±0.54)d,wheezing sound disappearance time(4.71±1.01)d in the observation group were shorter than those in the control group[(6.10±0.91)d,(5.93±0.61)d,(8.89±1.26)d].The difference was statistically significant(P<0.05).After treatment,the serum hyaluronic acid(HA)[(8.29±1.02)ng/ml],human laminin(LN)[(32.29±1.02)ng/ml]and PCⅢ[(22.57±3.21)pg/ml]in the observation group were lower than those of the control group[(11.24±1.62)ng/ml,(48.95±4.62)ng/ml and(35.68±4.57)pg/ml].The difference was statistically significant(P<0.05).Conclusion Salbutamol atomization combined with azithromycin is effective in the treatment of children with bronchial asthma.It can effectively improve the clinical symptoms and prevent airway remodeling,which is worthy of clinical promotion.