乳酸菌调控骨骼肌线粒体生物发生的机制研究进展

Recent Progress in Deciphering the Regulatory Mechanism of Lactic Acid Bacteria on Mitochondrial Biogenesis in Skeletal Muscle

作为高度动态化的细胞器,线粒体处于持续动态变化中,其生物发生对维持线粒体网络稳态至关重要,亦是调控肌纤维转化的新介质。乳酸菌可以通过诱导骨骼肌细胞内激酶活化、增强活性氧的信号诱导作用以及过氧化物酶体增殖物激活受体γ共激活因子1-α信号转录促进线粒体生物发生,进而影响肌纤维类型的转化。肌纤维类型与肉品质密切相关,因此,通过添加乳酸菌调控骨骼肌线粒体生物发生从而影响肌纤维类型的转化是未来改善肉品质的重要途径。本文综述了乳酸菌调控骨骼肌线粒体生物发生的分子机制,以及线粒体生物发生与肌纤维转化和肉品质之间的关系,以期为今后通过补充乳酸菌调控线粒体生物发生、促进肌纤维类型转化进而改善肉品质提供理论依据。

As highly dynamic organelles,mitochondria are in continuous dynamic change.Mitochondrial biogenesis is crucial to maintain mitochondrial network homeostasis,and is also a new medium to regulate the transformation of muscle fibers.Lactic acid bacteria can promote mitochondrial biogenesis by inducing the activation of intracellular kinase in skeletal muscle cells,enhancing signal induction of reactive oxygen species and peroxisome proliferator-activated receptor gamma co-activator-1αtranscription,thereby affecting the transformation of muscle fiber types.The type of skeletal muscle fibers is closely related to muscle quality.Therefore,the regulation of mitochondrial biogenesis by lactic acid bacteria to affect the transformation of muscle fiber types is considered an important way to improve meat quality in the future.This paper reviews the molecular mechanism by which lactic acid bacteria can regulate mitochondrial biogenesis in skeletal muscle,and the relationship of mitochondrial biogenesis with muscle fiber transformation and meat quality,which will provide a theoretical rationale for regulating mitochondrial biogenesis and promoting muscle fiber type transformation in order to improve meat quality by supplementing lactic acid bacteria in the future.