脑白质疏松发生机制及危险因素的研究进展

Research Progress in Pathogenesis and Risk Factors of Leukoaraiosis

脑白质疏松(LA)又称脑白质病变或白质高信号,是一种临床常见的神经系统影像学表现,其多见于老年人。近年来,随着LA的检出率逐渐升高,其越来越受到人们的关注。目前,有关LA的发生机制尚无统一定论,可能与脑缺血低灌注、血-脑屏障受损、静脉胶原增生沉积及遗传机制相关。年龄作为LA的危险因素已被广泛证实,而与LA相关的其他危险因素仍在积极研究中。LA对老年人的健康和生活质量均有不良影响,未来通过对LA发生机制及危险因素的进一步研究,将为LA的临床干预提供可能靶点。

Leukoaraiosis(LA),also known as white matter lesions or white matter hyperintensities,is a common clinical manifestation of neuroimaging,which is more common in the elderly.In recent years,with the increasing detection rate of LA,it has attracted more and more attention.At present,there is no unified conclusion about the mechanism of LA.The occurrence of LA may be related to cerebral ischemia-reperfusion,blood-brain barrier damage,vein collagen proliferation and deposition,and genetic mechanism.Age as a risk factor of LA has been widely confirmed,while other risk factors related to LA are still in active research.LA has adverse effects on the health and quality of life of the elderly.In the future,further study on the mechanism and risk factors of LA will provide a possible target for the clinical intervention of LA.