糖尿病肾脏病的发病机制研究进展

Pathogenesis Research Progress of Diabetic Kidney Disease

糖尿病肾脏病(DKD)作为糖尿病最主要的微血管并发症之一,已成为终末期肾病的主要病因,严重影响患者的生存及预后。DKD可通过多种途径损害肾脏,肾脏血管、肾小球和肾小管均可在疾病进展过程中受累,其发病机制较复杂,确切机制尚未明确。遗传因素、血流动力学效应、炎症反应、代谢紊乱、氧化应激和肾小球的病理改变及细胞损伤等多种因素可能共同参与DKD的发病。对DKD发病机制的进一步研究对DKD的临床治疗具有重要意义。

Diabetic kidney disease(DKD),as one of the most important microvascular complications of diabetes mellitus,has become the main cause of end-stage renal disease,which seriously affects the survival and prognosis of the patients.DKD can damage the kidney through a variety of ways.Renal vessels,glomeruli and tubules can all be involved in the process of the disease progression.The pathogenesis of DKD is complex,but the exact mechanism is not clear.Genetic factors,hemodynamic effects,inflammatory response,metabolic disorders,oxidative stress,glomerular pathological changes and cell damage may all be involved in the pathogenesis of DKD.Further study on the pathogenesis of DKD is of great significance for the clinical treatment.