基于VOSviewer生物医学领域3D打印的知识图谱分析

Knowledge mapping of three-dimensional printing in biomedical field based on VOSviewer

背景:近年3D打印技术在各个领域广泛应用,在医学领域的应用也日趋增多,为医学研究的发展提供了新的方向。目的:对近5年生物医学领域3D打印的相关文献进行可视化分析,探讨该领域的研究现状、热点和发展趋势。方法:检索PubMed数据库获取2015至2020年关于生物医学领域3D打印的相关文献,并通过文献PMID号在web of science核心集数据库获取这些文献的引用数据。用文献计量学方法对来源数据进行统计分析,利用VOSviewer软件对作者、机构、国家/地区及关键词进行分析,并绘制可视化图谱。结果与结论:①共纳入3471篇文献,近5年论文数量呈逐年上升趋势,根据指数趋势线可预测,发文量将保持增长,未来生物医学领域3D打印的研究将持续受到研究者关注;②共确定22种核心期刊,JCR分区Q≥2以上的期刊占比81.8%,期刊质量级别较高;③根据关键词共现聚类结果可把目前医学领域3D打印的研究方向分为临床应用、组织工程支架、药物制剂领域的应用和3D生物打印共4类;④VOSviewer可视化知识图谱分析显示,3D打印组织工程支架的材料选择和微观结构设计是近年研究热点,是拓展组织工程在临床应用的基础;⑤支架材料呈现出从单一同种向多种复合的发展趋势,支架的三维微观结构,包括孔隙率、孔径和相互连接的孔结构,在增强细胞活力和促进组织生长方面发挥着关键作用;⑥制备具有细胞活性的生物墨水是3D生物打印研究重点,具体热点包括:水凝胶、海藻酸盐和细胞外基质等生物支架材料性能、支架材料的交联和刚度以及干细胞打印等;⑦在3D打印药物制剂领域的应用方面,通过药物制剂打印技术、聚合物、纳米粒子和微流控芯片等热点研究,可实现药物释放系统的个性化设置。

BACKGROUND:In recent years,three-dimensional(3D)printing technology is widely used in various fields,and its application in the medical field is also increasing,which provides a new direction for the development of medical research.OBJECTIVE:To analyze the literature of 3D printing in biomedical field in recent 5 years,and illustrate the current research status,hot spots and development trends by using knowledge mapping analysis.METHODS:PubMed database was retrieved for related literature on 3D printing in biomedical field published from 2015 to 2020,and the citation relationship between articles was obtained from the core collection of web of science by PMID.The tool of bibliometrics and VOSviewer were used to analyze the author,organization,country and key words,and draw knowledge mapping.RESULTS AND CONCLUSION:(1)A total of 3471 articles were included.A trend toward an increasing number of publications in recent 5 years was evident.According to the index trend line,the number of papers will keep growing.In the future,the research of 3D printing in biomedical field will continue to attract the attention of researchers.(2)Among the 22 core journals identified,the percent of journals with JCR Q≥2 was 81.8%,and the quality of journals was high.(3)According to the keyword co-occurrence clustering results,the current research was divided into four categories:clinical application,tissue engineering scaffold,application in the field of pharmaceutical preparations,and 3D bioprinting.(4)VOSviewer knowledge mapping analysis showed that the selection of biomedical 3D printing tissue scaffold materials and scaffold microstructure design were the focus and hotspot in recent years and the basis of expanding clinical application of tissue engineering.(5)It was a trend from single to multiple composite materials in scaffold materials.The 3D microstructure of scaffolds,including porosity,pore size and interconnected pore structure,played a key role in enhancing cell viability and promoting tissue growth.(6)The preparation of bioink with cell activity was the focus of 3D bioprinting research,including the properties of biomaterial scaffolds,such as hydrogel,alginate and extracellular matrix,cross-linking and stiffness of scaffolds,and stem cell printing.(7)In the application of 3D printing pharmaceutical preparations,the personalized setting of drug delivery system is realized through the hotspot research,such as drug preparation printing technology,polymer,nanoparticles,and microfluidic chip.