重度子痫前期患者血清尿酸、AFP、hs-CRP及uE3水平与不良妊娠结局的相关性研究

The relationship between serum uric acid,AFP,hs-CRP and uE3 levels and adverse pregnancy outcome in severe preeclampsia

目的探讨重度子痫前期患者血清尿酸、甲胎蛋白(AFP)、超敏C反应蛋白(hs-CRP)和游离雌三醇(uE3)水平与不良妊娠结局的相关性。方法选取2019年6月至2020年7月本院收治的80例重度子痫前期患者,根据妊娠结局,分为不良妊娠结局组(n=32)和良好妊娠结局组(n=48)。比较两组血清尿酸、AFP、hs-CRP及uE3水平,同时分析血清尿酸、AFP、hs-CRP及uE3水平与不良妊娠结局的相关性。结果不良妊娠结局组的血清尿酸、AFP、hs-CRP水平均高于良好妊娠结局组,uE3水平低于良好妊娠结局组,差异均具有统计学意义(P<0.05);血清尿酸、AFP、hs-CRP水平升高为重度子痫前期患者不良妊娠结局的危险因素(P<0.05);uE3水平升高为重度子痫前期患者不良妊娠结局的保护因素(P<0.05)。结论血清尿酸、AFP、hs-CRP水平升高为重度子痫前期患者不良妊娠结局的危险因素,uE3水平升高为重度子痫前期患者不良妊娠结局的保护因素。

Objective To investigate the correlation between serum uric acid,alpha fetoprotein(AFP),high sensitive C-reactive protein(hs-CRP)and unconjugated estriol(uE3)levels and adverse pregnancy outcome in patients with severe preeclampsia.Methods 80 patients with severe preeclampsia admitted to our hospital from June 2019 to July 2020 were selected.According to the pregnancy outcome,they were divided into bad pregnancy group(n=32)and good pregnancy group(n=48).The levels of serum uric acid,AFP,hs-CRP and uE3 were compared between the two groups,and the correlation between serum uric acid,AFP,hs-CRP and uE3 and adverse pregnancy outcome was analyzed.Results The levels of serum uric acid,AFP and hs CRP in the adverse pregnancy group were higher than those in the good pregnancy group,and the level of uE3 was lower than that in the good pregnancy group,with statistical significance(P<0.05).The increase of serum uric acid,AFP and hs-CRP was the risk factor of adverse pregnancy outcome in severe preeclampsia(P<0.05).The increase of uE3 was the protection of adverse pregnancy outcome in severe preeclampsia Factors(P<0.05).Conclusion The increase of serum uric acid,AFP and hs-CRP is the risk factor of adverse pregnancy outcome in patients with severe preeclampsia,and the increase of uE3 is the protective factor of adverse pregnancy outcome in patients with severe preeclampsia.