腹膜假黏液瘤的基础研究进展

Advance on the Basic Research of Pseudomyxoma Peritonei

腹膜假黏液瘤是黏液癌的一种罕见亚型,大部分临床病例由阑尾黏液肿瘤在腹腔种植引发。腹膜假黏液瘤的发病机制仍不清楚,当前的临床治疗手段无法有效避免其复发。全文论述近年来腹膜假黏液瘤的基础研究进展,主要包括腹膜假黏液瘤动物模型研究、腹膜假黏液瘤中黏液分泌相关信号通路、降解黏液的物理化学方法研究,以及腹膜假黏液瘤中的基因突变研究等,以期为腹膜假黏液瘤的临床治疗提供参考。

Pseudomyxoma peritonei(PMP)is a rare subtype of mucinous adenocarcinoma.Most of the clinical PMP cases are caused by appendiceal mucinous neoplasms implantation in the abdominal cavity.The pathogenesis of PMP remains unclear.Current clinical treatments cannot effectively avoid PMP’s recurrence.This paper reviews the recent basic research progress of PMP,including the animal models of PMP,the signal pathways involved in mucus secretion of PMP,the physicochemical methods for mucus degradation,and the genetic mutations in PMP,in order to provide valuable references for clinical therapeutic strategies of PMP.