妇产科院内感染病原菌分布及耐药性分析

Pathogen distribution and antibiotic resistance of nosocomial infection in gynecological and obstetric patients

目的分析妇产科患者院内感染病原菌分布及耐药特点。方法回顾性分析2015年1月—2018年12月山东省济宁市任城区第二人民医院妇产科院内感染病例资料,采用《全国临床检验操作规程》标准分离、培养、鉴定病原菌,并进行药敏试验。统计医院感染情况,对病原菌的分布及耐药情况进行分析。结果158份临床标本共分离出病原菌192株,其中G-菌124株,占64.58%(124/192),G+菌56株,占29.17%(56/192);真菌12株,占6.25%(12/192)。G-菌中,大肠埃希菌最多(25%),铜绿假单胞菌占18.75%、鲍曼不动杆菌占17.19%。,G-杆菌大多对亚胺培南敏感,革兰阳性(G+)球菌未发现耐万古霉素。结论妇产科医院感染病原菌分布广泛,耐药率高,应尽早进行病原学检查及药敏试验,指导合理用药。

Objective To investigate the pathogen distribution and antibiotic resistance of nosocomial infection ingynecological and obstetric patients, so as to provide a reference for rational selection of clinical antibacterial drugs.Methods The samples of infected patients sent from the Obstetrics and Gynecology Department of the Second People’sHospital of Rencheng District, Jining City were selected from January 2015 to December 2018, and the bacteria were isolated,cultured, and identified, and the drug sensitivity results were determined according to the National Clinical Laboratory Oper-ating Procedures standards. The status of nosocomial infection, the distribution of pathogenic bacteria, and drug resistancewere retrospectively analyzed.Results A total of 192 strains of bacteria were isolated from 158 clinical specimens, of whichthere were 124 strains of G-bacteria, accounting for 64.58%(124/192), 56 strains of G+bacteria, accounting for 29.17%(56/192), and 12 strains of fungi, accounting for 6.25%(12/192). Among the G-bacteria, the top three were Escherichia coli(25%), Pseudomonas aeruginosa(18.75%), and Acinetobacter baumannii(17.19%). Most G-bacteria were sensitive to imipe-nem. G+cocci have not been found to be resistant to vancomycin.Conclusion Nosocomial pathogenic bacteria in gynecolog-ical and obstetric patients are widely distributed and the infection rate is high. Therefore, the etiological examinations anddrug susceptibility tests should be performed as soon as possible. Based on the results, the reasonable selection of antibacterialdrugs should be strengthened, so as to reduce the occurrence of bacterial drug resistance.