组蛋白脱乙酰酶在脂肪组织产热调控中的作用

Emerging roles of histone deacetylases in adipose tissue thermogenesis

肥胖是由机体能量代谢失衡所引起的营养性疾病,是2型糖尿病、脂肪性肝病、冠状动脉粥样硬化等疾病的主要危险因素[1-2]。脂肪是机体能量代谢的“调节中心”。除白色脂肪的储能作用外,棕色及米色脂肪还可以通过适应性非战栗性产热(adaptive non-shivering thermogenesis)的方式将能量散失。脂肪组织的产热调节在肥胖的病理生理过程中发挥重要作用,受多种蛋白的调控[3]。组蛋白脱乙酰酶(his⁃tone deacetylases,HDACs)可以广泛调节细胞内组蛋白及非组蛋白的乙酰化水平,继而影响脂肪组织的产热作用和肥胖的发生发展。

Brown and beige adipose tissues regulate body enegy expenditure through thermogenesis,which convertes energy into heat by oxidative phosphorylation uncoupling.As an important class of epigenetic modifying enzymes,histone deacetylases(HDACs)plays a role in adipose tissue thermogenesis through modulating chromatin structure,gene transcription as well as cellular signaling transduction by deacetylating histones and non-histone proteins.Different classes and isoforms of HDACs show diverse effects on the targets and processes of adipose tissue thermogenesis.In this review,we summarized the effects of HDACs and HDAC inhibitors on adipose tissue thermogenesis,in order to provide more reference for the treatment of obesity-related metabolic diseases.