山羊传染性胸膜肺炎免疫学诊断方法的研究进展

Advances in immunological diagnosis of contagious caprine pleuropneumonia

山羊传染性胸膜肺炎(contagious caprine pleuropneumonia,CCPP)是由山羊支原体山羊肺炎亚种(Mycoplasma capricolum subsp.capripneumoniae,Mccp)引起的山羊一种严重的呼吸道疾病,被世界动物卫生组织(OIE)列为法定报告疫病之一。CCPP流行区域横跨亚洲、中东和非洲40多个国家,目前已经报道数种可用于诊断该病的方法,其中涉及的免疫学诊断方法达10多种,但大多数方法存在敏感性差或特异性低的问题。本文对常用于CCPP诊断的免疫学方法以及有关诊断靶标挖掘工作做概述,总结各方法的优缺点和适用范围,以期为免疫学诊断方法的更好应用和改进提供参考。

Contagious caprine pleuropneumonia(CCPP)is a serious respiratory disease of goats caused by Mycoplasma capricolum subsp.Capripneumoniae(Mccp),which is one of the listed diseases of the world organization for animal health(OIE).CCPP have been reported in more than 40 countries,which cover Asia,the Middle East,Africa.At present,a variety of technologies published in literatures can be used to diagnose the disease,which include dozens of immunological diagnosis methods.But most of those have sensitivity or specificity problems.This paper mainly gives an overview of the CCPP immunological diagnosis methods and the existing work on the diagnositic targets,and summarizes the advantages,disadvantages and scope of each method,as to provide useful information for better application and improvement of those methods.