溶瘤病毒在神经胶质瘤治疗中的研究进展

Progress in oncolytic virotherapy for the treatment of glioma

神经胶质瘤是增殖能力强、复发率高的原发性脑肿瘤,手术、放化疗等传统疗法效果较差,因此需要寻找更加有效的治疗方法。溶瘤病毒作为新型免疫疗法已被证明具有靶向性强、溶瘤效果显著及副作用少等优势。近年来溶瘤病毒在神经胶质瘤的临床治疗上取得一些突破性进展,其安全性和有效性得到了验证。现对近几年来溶瘤病毒单药治疗及与放化疗、免疫疗法等其他手段联合治疗神经胶质瘤的临床前研究和临床试验进展作详细介绍,对现阶段存在的问题进行讨论,并对未来研究进行展望。

Glioma is a primary brain tumor with strong proliferation capacity and high recurrence rate.It has a dismal outcome despite the use of traditional treatments including surgery,radiation therapy and chemotherapy.Thus,there is an urgent need for effective therapies for patients with glioma.Oncolytic virus is an immunotherapy method,which has the advantages of strong targeting,significant oncolytic effect and low side effects.Recently,oncolytic virotherapy has achieved some breakthrough in treating glioma,its safety and efficacy have been proved.This article mainly introduces the results of preclinical experiments and clinical trials of oncolytic virus monotherapy and its combination with other treatments like radiation therapy,chemotherapy and immunotherapy in recent years,and discusses the problems existing at this stage and the future research directions of glioma by oncolytic virus therapy.