食管上段异位胃黏膜危险因素的研究

Study on the Risk Factors of Heterotopic Gastric Mucosa of Upper Esophagus

背景:近年食管上段异位胃黏膜(HGMUE)逐渐受到重视,HGMUE引起的食管狭窄、食管网、异型增生和食管上段腺癌的发生率逐渐增高。目的:总结HGMUE患者的临床病理特点,分析其可能的危险因素。方法:收集2018年9月—2019年10月新疆维吾尔自治区人民医院确诊的150例HGMUE患者,以150例非HGMUE患者作为对照。对HGMUE的相关危险因素行单因素分析和多因素分析。结果:单因素分析结果显示,HGMUE组饮酒(P=0.029)、合并Barrett食管(P=0.003)、合并反流性食管炎(P=0.001)的发生率显著高于对照组,而两组性别、年龄、BMI、吸烟史、PPI服用史、阿司匹林服用史、是否合并食管裂孔疝、Hp感染、消化性溃疡相比差异无统计学意义。非条件多因素Logistic回归分析显示,饮酒、合并Barrett食管或反流性食管炎均为HGMUE的独立危险因素(P<0.05)。结论:饮酒、合并Barrett食管或反流性食管炎可提高患HGMUE的风险。

Background:Heterotopic gastric mucosa of upper esophagus(HGMUE)earned attention gradually in recent years,and the incidences of esophageal stenosis,esophageal net,dysplasia and adenocarcinoma of upper esophagus caused by HGMUE increased gradually.Aims:To summarize the clinicopathological features of HGMUE patients and analyze its possible risk factors.Methods:A total of 150 HGMUE patients from September 2018 to October 2019 at the People’s Hospital of Xinjiang Autonomous Region were collected,and 150 non-HGMUE patients were served as controls.Univariate analysis and multivariate analysis were used to analyze the risk factors of HGMUE.Results:Univariate analysis showed that the incidences of alcohol consumption(P=0.029),Barrett’s esophagus(P=0.003)and reflux esophagitis(P=0.001)were significantly increased in HGMUE group than in control group.Unconditional multivariate Logistic regression analysis showed that alcohol consumption,Barrett’s esophagus and reflux esophagitis were the independent risk factors of HGMUE(P<0.05).Conclusions:Alcohol consumption,Barrett’s esophagus and reflux esophagitis can increase the risk of HGMUE.