供精人工授精生化妊娠与早期流产周期特点比较分析

Characteristics of biochemical pregnancy vs early abortion cycles of artificial insemination by donor

目的探究供精人工授精(AID)不良妊娠结局类型的影响及预测指标。方法对2009年11月至2019年6月实施的AID周期中的67个生化妊娠周期与90个早期流产周期的周期特点进行了回顾性分析。结果2种不良妊娠结局的人工授精(AI)后14 d血清β-绒毛膜促性腺激素(HCG)水平及比例分布差异有统计学意义(P<0.01),早期流产患者的平均不孕年限显著长于生化妊娠患者(P<0.05),其余周期特点评价指标在2种不良妊娠组间的差异均无统计学意义(P>0.05)。结论患者AI后14 d血清β-HCG水平、不孕年限、AI日子宫内膜形态可作为行AID助孕后不良妊娠结局类型的(潜在)预测指标。至于其具体影响效果及应用价值,仍需进一步研究。

Objective To investigate the impacts and predictors of the adverse pregnancy outcomes in artificial insemination by donor(AID).Methods A retrospective statistical analysis was performed to compare the characteristics of 67 biochemical pregnancy cycles and 90 early abortion cycles in AID between November 2009 and June 2019.Results Between these two adverse pregnancy outcomes,there was a significant difference in the value and distribution of serum β-HCG levels at 14 days after AID(P<0.01).The mean length of infertility was significantly longer in patients with early abortion than those with biochemical pregnancy(P<0.05).The remaining indicators of cycle characteristics did not differ between the two adverse pregnancy outcomes(P>0.05).Conclusion The 14-day serum β-HCG level,length of infertility,and endometrial morphology on the day of AI may be used as potential preditors of adverse pregnancy outcomes after AID.Further studies are needed to determine their specific impacts and clinical value.