高强度聚焦超声治疗子宫肌瘤的临床效果及安全性

Clinical efficacy and safety of high intensity focused ultrasound in treatment of uterine fibroids

目的探讨高强度聚焦超声治疗子宫肌瘤的临床效果及安全性,为该方式普及提供理论依据。方法选取2018年2月至2019年10月本院收治的子宫肌瘤患者80例,所有患者均采用高强度聚焦超声治疗,比较患者治疗半年后子宫和子宫肌瘤体积变化,治疗后即刻不良反应及治疗后半个月情况,评价其临床疗效和安全性。结果子宫肌瘤治疗后PSV为(5.92±1.12)、Vmean为(3.18±0.87)、管径为(0.12±0.06)、血流量为(0.25±0.09),均低于治疗前的(23.05±5.47)、(14.10±3.12)、(0.35±0.14)、(1.15±0.36);治疗前子宫体积为(83.62±8.98)、子宫肌瘤体积为(40.32±2.62),均高于治疗半年后的(59.25±5.43)、(19.92±1.20);差异有统计学意义(均P<0.05)。子宫肌瘤患者治疗后即刻均会出现不良反应,57.50%患者出现下腹疼痛,21.25%患者出现骶部疼痛,26.25%患者出现阴道排液,5.00%患者出现恶心呕吐,但无严重并发症,且不良反应均在治疗后半个月恢复正常。结论子宫肌瘤患者采取高强度聚焦超声治疗效果显著,能减小子宫和子宫肌瘤体积,且安全性较高,应推广应用。

Objective To explore the clinical efficacy and safety of high intensity focused ultrasound in the treatment of uterine fibroids,and to provide theoretical basis for generalizing this method.Methods A total of 80 patients with uterine fibroids admitted to our hospital from February,2018 to October,2019 were treated with high-intensity focused ultrasound;and the changes in uterine and fibroid volumes half a year after the treatment,adverse reactions immediately after the treatment,and the situation half a month after the treatment were compared to evaluate the clinical efficacy and safety.Results The PSV,Vmean,diameter,and blood flow were lower after than before the treatment[(5.92±1.12)vs.(23.05±5.47),(3.18±0.87)vs.(14.10±3.12),(0.12±0.06)vs.(0.35±0.14),and(0.25±0.09)vs.(1.15±0.36)].The uterine volume and fibroid volume were(83.62±8.98)and(40.32±2.62)before the treatment,and were(59.25±5.43)and(19.92±1.20)half a year after the treatment;there were statistical differences(both P<0.05).All the patients had adverse reactions immediately after the treatment;57.50%of the patients got quadrant abdominal pain,21.25%sacral pain,26.25%vaginal drainage,and 5.00%nausea and vomiting;no serious complications occurred;and all the adverse reactions were recovered within half month.Conclusion High intensity focused ultrasound is effective and relatively safe in treatment of uterine fibroids,and can reduce the size of uterus and uterine fibroids,so it should be popularized.