维生素K对肝硬化患者凝血功能、血小板的影响

Impact of intravenous vitamin K on coagulation and platelet in patients with liver cirrhosis

目的观察补充维生素K对肝硬化患者的治疗情况以及凝血相关参数的影响。方法回顾性分析本院2016年1月至2018年1月诊断为肝硬化的114例使用维生素K静脉注射治疗的患者用药情况以及用药前后相关凝血指标的变化,同时选择健康个体100例作为健康对照组。结果肝硬化患者治疗前PT[(18.27±4.53)s]、APTT[(46.43±4.52)s]明显延长,PLT[(71.34±28.32)×10^9/L]、Fib[(1.82±0.41)g/L]明显降低,INR[(1.53±0.34)]明显高于对照组(均P<0.05)。与治疗前相比,肝硬化患者经维生素K治疗后PT[(14.98±3.75)s]、APTT[(38.31±4.86)s]明显缩短,PLT[(82.31±46.14)×10^9/L]、Fib[(2.25±0.64)g/L]明显增加,INR(1.22±0.53)明显降低(均P<0.05)。肝损伤严重程度增加,PT、APTT延长,PLT、Fib降低,INR增加越明显(均P<0.05)。结论维生素K对肝硬化患者凝血功能、血小板数有一定改善作用。

Objective To investigate the effect of vitamin K administration for patients with liver cirrhosis on coagulation function.Methods This retrospective study analyzed the medication and coagulation changes on 114 patients diagnosed with liver cirrhosis from Jan.,2016 to Jan.,2018.100 healthy people were considered as controls.Results Before the treatment,the PT,APTT,PLT,Fib,and INR were(18.27±4.53)s,(46.43±4.52)s,(71.34±28.32)×10^9/L,(1.82±0.41)g/L,and(1.53±0.34)in the patients,which were statistically different from than those in the controls(all P<0.05).After the treatment,the PT,APTT,PLT,Fib,and INR were(14.98±3.75)s,(38.31±4.86)s,(82.31±46.14)×10^9/L,(2.25±0.64)g/L,and(1.22±0.53),which were better than those before the treatment(all P<0.05).As the severity of liver cirrhosis increased,the PT and APTT prolonged,PLT and Fib decreased,and INR increased(all P<0.05).Conclusion The use of vitamin K may play a role in correcting coagulation and PLT of patients with liver cirrhosis.