化妆品经皮渗透研究进展——评价方法及促渗技术

Progress in research of skin permeability of cosmetics Evaluation method and enhancement technology

对于化妆品中应用的经皮递送系统,列举常见的促渗方法,包括化学促渗技术、纳米技术(纳米乳液、纳米晶体、脂质体、类脂囊泡、微胶粒等)、物理促渗技术(离子导入、超声导入、微针)以及生物促渗技术等。对化妆品体外透皮吸收试验方法(体外扩散池法、数学模型、三维皮肤模型、液质联用、拉曼光谱)进行了简单介绍,并对化妆品经皮渗透方法进行了展望。

For the transdermal delivery system used in cosmetics,the common methods for promoting penetration have been listed,including chemical permeation-enhancing techniques,nanotechnology(nanoemulsions,nanocrystals,liposomes,niosomes,micelles,etc.),physical permeation-enhancing techniques(iontophoresis,ultrasonic introduction,and microneedle)and biological permeability-promoting technology.The testing methods of transdermal absorption of cosmetics in vitro(in-vitro diffusion cell method,mathematical model,three-dimensional skin model,LC-MS,and Raman spectroscopy)have been briefly introduced,and the future transdermal penetration methods of cosmetics have been prospected.