临床输血患者红细胞血型不规则抗体检测的临床意义分析

Analysis of clinical Significance of irregular Antibody Detection of RBC Blood Group in Patients undergoing clinical Blood Transfusion

目的探究输血前给予输血患者红细胞血型不规则抗体检测的意义。方法选择2019年1月至2020年1月到本院行输血治疗的1000例患者为研究对象,所有患者均行红细胞血型不规则抗体检测,对比血型不规则抗体的阳性检出率。结果对比分析发现,女性患者不规则抗体阳性率明显高于男性患者(P<0.05);有妊娠史、输血史的患者不规则抗体阳性率高于无妊娠史、输血史的患者(P<0.05)。1000例患者不规则抗体阳性59例,阳性率为5.9%。同种特异性抗体51例(86.44%),其中Rh血型系统24例(47.06%),MNS血型系统11例(21.75%),Lewis血型系统10例(19.61%),P血型系统6例(11.76%);非特异性抗体8例(13.56%),其中冷抗体5例(62.50%),自身抗体3例(37.50%)。结论给予血液疾病治疗患者不规则抗体筛查,对预防多种血液疾病的发生有着重要意义,可保证临床用血安全,降低输血不良事件的发生。

Objective To explore the significance of irregular antibody detection of RBC blood group in patients before blood transfusion.Methods From January 2019 to January 2020,1000 patients who received blood transfusion in our hospital were selected as the study subjects.All patients were tested for red blood cell irregular antibody,and the positive rate of irregular antibody was compared.Results The positive rate of irregular antibody in female patients was higher than that in male patients(P<0.05),and the positive rate of irregular antibody in patients with pregnancy history and blood transfusion history was higher than that in patients without pregnancy history and blood transfusion history(P<0.05).The positive rate of irregular antibody was 5.9%(59/1000).There were 51 cases(86.44%)of allo-specific antibody,including 24 cases(47.06%)of RH blood group system,11 cases(21.75%)of MNS blood group system,10 cases(19.61%)of Lewis blood group system,6 cases(11.76%)of P blood group system,8 cases(13.56%)of non-specific antibody,5 cases(62.50%)of cold blood group,autoantibodies in 3 cases(37.50%).Conclusion Irregular antibody screening for patients with blood diseases is of great significance to prevent the occurrence of various blood diseases,it can ensure the safety of clinical blood use and reduce the adverse events of blood transfusion.