凝血四项+CHE水平检测对病毒性肝炎患者阳性检出率的影响

Effect of four levels of coagulation+CHE on the positive detection rate of patients with viral hepatitis

目的研究凝血四项联合血清胆碱酯酶(CHE)水平检测对病毒性肝炎患者阳性检出率的影响。方法选取本院接收的76例病毒性肝炎患者作为研究组,另选同期健康体检者45例作为对照组。检测并比较对照组、研究组不同病情肝炎患者的凝血四项[纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)]及血清CHE水平,对比凝血四项及血清CHE单独诊断及二者联合诊断病毒性肝炎患者的阳性检出率。结果研究组FIB及血清CHE水平显著低于对照组,PT、APTT、TT水平显著高于对照组(P<0.05);研究组急性肝炎、慢性肝炎、肝炎后肝硬化、重型肝炎患者的FIB、PT、APTT、TT及血清CHE水平存在显著差异,FIB及血清CHE水平由高到低依次为急性肝炎、慢性肝炎、肝炎后肝硬化、重型肝炎,PT、APTT、TT水平由低到高依次为急性肝炎、慢性肝炎、肝炎肝硬化、重型肝炎(P<0.05);凝血四项联合血清CHE诊断急性肝炎、慢性肝炎、肝炎后肝硬化、重型肝炎患者的阳性检出率(88.89%、97.37%、94.74%、100.00%)均显著高于二者单独诊断(P<0.05)。结论病毒性肝炎患者FIB及血清CHE水平呈异常低表达状态,PT、APTT、TT水平呈显著高表达状态,且不同病情肝炎患者的凝血四项与血清CHE水平不同,凝血四项联合血清CHE能显著提高病毒性肝炎患者阳性检出率,可为临床诊治病毒性肝炎患者提供重要数据参考。

Objective To study the effect of four blood coagulation combined with serum cholinesterase(CHE)levels on the positive detection rate of patients with viral hepatitis.Methods 76 patients with viral hepatitis received by our hospital were selected as the study group,and 45 healthy controls were selected as the control group.Detect and compare four blood coagulation factors[fibrinogen(FIB),prothrombin time(PT),activated partial thrombin time(APTT),thrombin time(TT)]and serum in the control group and the study group.The CHE level was compared with the positive detection rate of four patients with blood coagulation and serum CHE alone and in combination with diagnosis of viral hepatitis.Results The levels of FIB and serum CHE in the study group were significantly lower than those in the control group.The levels of PT,APTT and TT were significantly higher than those in the control group(P<0.05).The acute hepatitis,chronic hepatitis,post-hepatitic cirrhosis,FIB of patients with severe hepatitis were studied in the study group.There were significant differences in PT,APTT,TT and serum CHE levels.The levels of FIB and serum CHE from high to low were acute hepatitis,chronic hepatitis,posthepatitis cirrhosis and severe hepatitis.The levels of PT,APTT and TT were from low to high.Acute hepatitis,chronic hepatitis,hepatitis cirrhosis,severe hepatitis(P<0.05);positive detection rate of four patients with blood coagulation combined with serum CHE in the diagnosis of acute hepatitis,chronic hepatitis,post-hepatitic cirrhosis,severe hepatitis(88.89%,97.37%,94.74%,100.00%)were significantly higher than the two diagnoses alone(P<0.05).Conclusion The levels of FIB and serum CHE in patients with viral hepatitis are abnormally low,and the levels of PT,APTT and TT are highly expressed.The blood coagulation of four patients with different hepatitis patients is different from serum CHE.Significantly improve the positive detection rate of patients with viral hepatitis,can provide important data reference for clinical diagnosis and treatment of viral hepatitis patients.