瘦素保护认知损害的作用机制研究进展

Research Progress on the Protective Mechanism of Leptin on Cognitive Impairment

认知损害是从轻度认知损害至痴呆的一系列临床状态,以不可逆性损害患者的认知功能及生活自理能力为临床特点,给患者及其家庭乃至当今老龄化社会带来沉重负担。肥胖是认知损害重要的代谢性危险因素之一,瘦素是一种脂肪源性激素,其水平变化与肥胖相关的合并症如2型糖尿病、心血管疾病和神经退行性疾病密切相关。文中就瘦素与认知损害关系的临床研究以及瘦素的神经保护机制作综述,为认知损害的预防和治疗提供思路。

Cognitive impairment is a series of clinical manifestations from mild cognitive dysfunction to dementia. Due to the irreversible dysfunction of patients’ cognitive function and self-care ability, it brings a heavy burden to patients, their families and even the aging society. Obesity is one of the important metabolic risk factors of cognitive dysfunction, and leptin is an adipocyte-derived hormone, and its concentration changes are closely related to obesity-related complications such as type 2 diabetes, cardiovascular disease and neurodegenerative diseases. The clinical researchs and mechanisms of leptin in cognitive dysfunction to provide new ideas for the prevention and treatment of cognitive impairment were reviewed.