口服降糖药曲格列酮的核磁共振谱学表征

Nuclear Magnetic Resonance Characterization of Oral Hypoglycemic Drug Troglitazone

利用NMR,IR,UV及MS等实验技术研究了胰岛素增敏剂曲格列酮的波谱学特征.结合DEPT谱及1H-1HCOSY,13C-1HHETCOSY,13C-1HLC-HETCOSY对曲格列酮的氢谱和碳谱进行完全归属.

The NMR spectra are reported for troglitazone (5oxy2,5,7phenyl]methyl]2,4thiazolidinedione) that is used as an oral hypoglycemic drug. By using DEPT, 1H1H COSY,13C1H HETCOSY and 13C1H LCHETCOSY techniques along with IR, UV and MS, the proton and 13C spectra of troglitazone are assigned completely. This result also provides a basis analysis for the NMR characterization of the similar new drugs.