特异性免疫治疗支气管哮喘的机制及对肺功能的影响

Mechanism of allergen specific immunotherapy and its influence on lung function in asthma children

支气管哮喘(哮喘)是儿童一种常见的反复发作的慢性气道炎症性病变。目前临床上主要应用β2受体激动剂快速缓解症状及吸入糖皮质激素进行长期控制。变应原特异性免疫治疗(AIT)可以调整哮喘的自然病程,对控制哮喘症状、降低气道高反应、改善肺功能有一定疗效,是目前唯一针对病因的治疗方案。现就AIT治疗哮喘的机制及对肺功能的影响方面进行综述,为提高其临床疗效提供依据。

Asthma is a common chronic airway inflammatory disease in children.Currently,symptomatic control can be achieved in the majority of patients through a combination of β2 receptor agonists for rapid relief of symptoms and inhaled corticosteroids for long-term control.As the only causal treatment modality at present,allergen-specific immunotherapy(AIT)may modify the natural course of asthma,and can control the symptoms,reduce airway hyperresponsiveness and improve lung function.In order to provide evidence for improving the effect of AIT on asthma,the mechanism of AIT in asthma and its effect on lung function were discussed in this paper.