摘要
新型冠状病毒(SARS-CoV-2)感染引起的新型冠状病毒肺炎(COVID-19)患者临床表现出不同程度的肝损伤。一系列研究表明细胞因子风暴、SARS-CoV-2病毒所致的胆管细胞损伤以及药物性肝毒性可以诱导继发性肝损伤,对不同因素所致的肝损伤的机制以及保肝药物治疗进行综述,以期为后续深入揭示该方面的研究提供参考支持。
COVID-19 patients infected with SARS-CoV-2 showed different degrees of liver injury.A series of studies have shown that cytokine storm,bile duct cell injury caused by SARS-CoV-2 and drug-induced hepatotoxicity can induce secondary liver injury.This article will review the mechanism of liver injury caused by different factors and the treatment of hepatoprotective drugs,in order to provide reference support for further research in this field.
作者
张津
张文静
ZHANG Jin;ZHANG Wenjing(Department of Pharmacy,Changhai hospital,Naval Medical University,Shanghai 200433,China;Tenth People´s Hospital Affiliated to Tongji University,shanghai 200072,China)
出处
《药学实践杂志》
CAS
2020年第6期481-484,共4页
Journal of Pharmaceutical Practice
基金
上海市卫生计生委重要薄弱学科建设项目(2016ZB0303-01)。
