艾司洛尔治疗儿童重症手足口病疗效的系统评价和Meta分析

Systematic Review and Meta-Analysis of Esmolol in the Treatment of Severe Hand-Foot-Mouth Disease in Children

目的:系统评价艾司洛尔治疗儿童重症手足口病的临床疗效。方法:计算机检索中国学术期刊全文数据库、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、EMBase、the Cochrance Library数据库,收集从建库至2018年12月所有艾司洛尔治疗儿童重症手足口病的随机对照试验(对照组采用常规治疗,试验组在常规治疗基础上加用艾司洛尔)。提取符合纳入标准的文献并进行质量评价,运用RevMan 5.3进行Meta分析。结果:共纳入6项研究,包括700例患儿。Meta分析结果显示,试验组治疗后血清内乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、去甲肾上腺素(NE)水平均低于对照组(P<0.05)。结论:对于重症手足口病患儿,在常规治疗基础上加用艾司洛尔可提高疗效。

Objective:To systematically evaluate the clinical efficacy of esmolol in the treatment of severe hand-foot-mouth disease in children.Methods:CNKI,Wanfang database,VIP database,CBM,PubMed,EMBase,the Cochrance Library were retrieved to collect the randomized controlled trials of esmolol in the treatment of severe hand-foot-mouth disease in children(the control group was treated with conventional therapy,and the experimental group received aselol on the basis of conventional therapy).According to inclusion and exclusion criteria,qualified literature was screened for evaluation,data was extracted and Meta-analysis was performed with RevMan 5.3.Results:A total of 6 related studies were collected,including 700 children.Meta-analysis showed that the serum levels of lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB)and norepinephrine(NE)in the experimental group after treatment were lower than those in the control group(P<0.05).Conclusion:For the children with severe hand-foot-mouth disease,the clinical efficacy can be improved by the addition of aselol on the basis of conventional treatment.