非布司他片对慢性肾功能不全并发高尿酸血症患者肾功能及炎症因子影响研究

Effects of Febuxostat Tablets on Renal Function and Inflammatory Fctors in Patients with Chronic Renal Insufficiency Complicated with Hyperuricemia

探究碳酸氢钠片联合非布司他片对慢性肾功能不全并发高尿酸血症患者临床效果。将2017年1月至2018年8月在该院就诊的92例慢性肾功能不全并发高尿酸血症患者根据治疗方法的不同分为对照组(n=44)和实验组(n=48),对照组给予碳酸氢钠片,实验组给予碳酸氢钠片联合非布司他片治疗;对比分析两组患者肾功能、炎症因子等指标变化。治疗前,两组患者BUN、U-mAlb、Scr、SUA、GFR、TNF-α、IL-1β、IL-6、ET-1差异不显著(P>0.05)。治疗后,两组患者BUN、U-mAlb、Scr、SUA、TNF-α、IL-6、ET-1均显著的低于治疗前(P<0.05);实验组BUN(7.05±1.02)mmol/L、U-mAlb(126.53±55.72)mmol/L、Scr(87.26±29.26)umol/L、SUA(376.15±74.63)umol/L均显著优于对照组(P<0.05)。实验组SUA降低20%时间为(5.42±1.24)w、降低40%时间为(8.03±1.13)w,均显著短于对照组(P<0.05);治疗后,两组患者GFR均显著的高于治疗前(P<0.05),且实验组GFR为(86.28±9.27)m L/min,显著高于对照组(P<0.05);实验组GFR分期1期(11/22.92%)显著高于对照组(P<0.05),实验组3期(3/6.25%)显著低于对照组(P<0.05);治疗后,实验组TNF-α(38.86±0.89)ng/L、IL-1β(45.69±2.27)ng/L、IL-6(35.52±2.21)ng/L、ET-1(31.72±6.27)ng/L均显著的低于对照组(P<0.05)。碳酸氢钠片对慢性肾功能不全并发高尿酸血症患者肾功能均具有一定的改善作用,但联合非布司他片可显著的改善患者肾功能,增强肾小球滤过率能力,减小炎性反应。

To explore the clinical effect of sodium bicarbonate tablets combined with febustatin tablets in patients with chronic renal insufficiency complicated by hyperuricemia,from January 2017 to August 2018,92 patients with chronic renal insufficiency complicated by hyperuricemia treated in the hospital were divided into control group(n=44)and experimental group(n=48)according to different treatment methods.The changes of renal function and inflammatory factors in the two groups were compared and analyzed.The result showed before treatment,there was no significant difference in BUN,U-mAlb,Scr,SUA,GFR,TNF-α,IL-1β,IL-6,ET-1 between the two groups(P>0.05).After treatment,BUN,U-mAlb,Scr,SUA,TNF-α,IL-6,ET-1 were significantly lower in the two groups than before treatment(P<0.05).Experimental group BUN(7.05±1.02)mmol/L,u-malb(126.53±55.72)mmol/L,Scr(87.26±29.26)μmol/L,SUA(376.15±74.63)μmol/L were significantly lower than the control group(P<0.05).The reduction time of SUA in the experimental group was 20%(5.42±1.24)weeks and 40%(8.03±1.13)weeks,both significantly shorter than that in the control group(P<0.05).After treatment,GFR in both groups was significantly higher than that before treatment(P<0.05),but GFR in the experimental group(86.28±9.27)m L/min was significantly higher than that in the control group(P<0.05).GFR stage 1(11/22.92%)in the experimental group was significantly higher than that in the control group(P<0.05),and stage 3(3/6.25%)in the experimental group was significantly lower than that in the control group(P<0.05).After treatment,TNF-α(38.86±0.89)ng/L,IL-1β(45.69±2.27)ng/L,IL-6(35.52±2.21)ng/L,and ET-1(31.72±6.27)ng/L in the experimental group were significantly lower than those in the control group(P<0.05).Sodium bicarbonate tablets can improve renal function in patients with chronic renal insufficiency complicated with hyperuricemia,but it combined with febustatin tablets can significantly improve renal function in patients,enhance glomerular filtration rate and reduce inflammatory response,and have a good clinical effect.